Resource

Clopidogrel

Overview: Learn more about the anti-platelet drug, clopidogrel (Plavix) and how variants in the CYP2C19 gene influence clopidogrel metabolism.

Experts from the disciplines listed below have tagged this resource as fulfulling genomic competencies.

Basic Genetic Concepts
- B3: To identify drug and disease associated genetic variations that facilitate development of prevention, diagnostic and treatment strategies and appreciate there are differences in testing methodologies and are aware of the need to explore these differences in drug literature evaluation
Ethical, Legal and Social Implications (ELSI)
- E3: To adopt a culturally sensitive and ethical approach to patient counseling regarding genomic/pharmacogenomic test results
- E5: To Identify the need to refer a patient to a genetic specialist or genetic counselor
Pharmacogenetics/Pharmacogenomics
- P1: To demonstrate an understanding of how genetic variation in a large number of proteins, including drug transporters, drug metabolizing enzymes, direct protein targets of drugs, and other proteins (e.g. signal transduction proteins) influence pharmacokinetics and pharmacodynamics related to pharmacologic effect and drug response

Patient Care
- 5: Discuss the range of genetic and genomic-based approaches to the treatment of disease.
Medical Knowledge For Practice
- 2: Define the role of genetic variation in health and disease