IGNITE Supporting Practice through Application, Resources, and Knowledge (SPARK) Toolbox

Implementing GeNomics In pracTicE (IGNITE) is an NIH/NHGRI-funded network dedicated to supporting the implementation of pharmacogenomics in healthcare. The network is comprised of six research sites, a coordinating center, a steering committee, and working and interest groups. The IGNITE Network also disseminates the methods and best practices its members develop in order to advance the implementation of genomics in healthcare. One outlet for public distribution is the SPARK Toolbox, which provides genomic medicine resources for clinicians, researchers, educators, and patients.


Type Website
CME Available No
Topic
Cost Free
Note


Date of Resource 2019

Genomic Competencies

Experts from the disciplines listed below have tagged this resource as fulfulling genomic competencies.

Pharmacist

  • Pharmacogenetics/Pharmacogenomics
    • P1:   To demonstrate an understanding of how genetic variation in a large number of proteins, including drug transporters, drug metabolizing enzymes, direct protein targets of drugs, and other proteins (e.g. signal transduction proteins) influence pharmacokinetics and pharmacodynamics related to pharmacologic effect and drug response
    • P2:   To understand the influence (or lack thereof) of ethnicity in genetic polymorphisms and associations of polymorphisms with drug response
    • P3:   Recognize the availability of evidence based guidelines that synthesize information relevant to genomic/pharmacogenomic tests and selection of drug therapy (e.g. Clinical Pharmacogenomics Implementation Consortium)

Physician Assistant

  • Patient Care
    • 5:   Discuss the range of genetic and genomic-based approaches to the treatment of disease.
  • Practiced-based Learning and Improvement
    • 1:   Use information technology to obtain current and credible information about genetics for self, patients, and colleagues

Nurse

  • Professional Responsibilities
    • PR-2:   Advocate for clients' access
      • PR2-K1:   Resources for healthcare professionals and lay public
        • PR2-1:   Demonstrate appropriate care and concern for all clients throughout their referral, provision of direct care and follow-up to genetic services.
        • PR2-2:   Demonstrate knowledge about accessing local/regional genetic and/or genomic resources.
        • PR2-3:   Include genetic health care professionals in team building and collaborative strategies to optimize client outcomes.
        • PR2-4:   Help client negotiate system barriers that limit access to genetic/genomic services.
        • PR2-5:   Identify strategies that could be used to facilitate reimbursement for access to genetic/genomic services and/or tests.
      • PR2-K2:   Resources for genetic and/or genomic referrals within one's community
        • PR2-1:   Demonstrate appropriate care and concern for all clients throughout their referral, provision of direct care and follow-up to genetic services.
        • PR2-2:   Demonstrate knowledge about accessing local/regional genetic and/or genomic resources.
        • PR2-3:   Include genetic health care professionals in team building and collaborative strategies to optimize client outcomes.
        • PR2-4:   Help client negotiate system barriers that limit access to genetic/genomic services.
        • PR2-5:   Identify strategies that could be used to facilitate reimbursement for access to genetic/genomic services and/or tests.
    • PR-4:   Incorporate genetic and genomic technologies and information into practice.
      • PR4-K1:   Technology and information systems
        • PR4-1:   Evaluate genetic and genomic technologies used in client care.
        • PR4-2:   Demonstrate use of genetic and genomic technology and client data for clinical decision-making in providing safe client care.
        • PR4-3:   Identify the credibility, reliability and limitations of genetic and genomic information.
        • PR4-4:   Identify ethical, legal, and social issues associated with genetic/genomic information.
  • Nursing Assessment
    • NA-8:   Develop a plan of care that incorporates genetic and genomic assessment information.
      • NA8-K1:   Interprofessional plan of care
        • NA8-1:   Develop, in partnership with the client, a health care plan that takes into account genetic and genomic determinants of health, available resources, and range of activities that contribute to health and prevention of illness, injury, disability and premat
        • NA8-2:   Integrate best evidence, clinical judgment, client preferences, and family implications in planning genetic and genomic focused individualized care.
  • Referral activities
    • RA-1:   Facilitate referrals for specialized genetic and genomic services
      • RA1-K1:   Professional roles of providers delivering genetic and genomic services
        • RA1-1:   Develop an interprofessional plan of care in collaboration with the client that incorporates genetics and genomics.
        • RA1-2:   Uses genetic and genomic indicators as rationale for clients who may benefit from further evaluation or other risk management interventions.
        • RA1-3:   Develop a plan for follow-up of a client post genetics/genomic referral.
      • RA1-K2:   Resources for health care professionals and lay public
        • RA1-1:   Develop an interprofessional plan of care in collaboration with the client that incorporates genetics and genomics.
        • RA1-2:   Uses genetic and genomic indicators as rationale for clients who may benefit from further evaluation or other risk management interventions.
        • RA1-3:   Develop a plan for follow-up of a client post genetics/genomic referral.
      • RA1-K3:   Resources for genetic and genomic referrals within the community
        • RA1-1:   Develop an interprofessional plan of care in collaboration with the client that incorporates genetics and genomics.
        • RA1-2:   Uses genetic and genomic indicators as rationale for clients who may benefit from further evaluation or other risk management interventions.
        • RA1-3:   Develop a plan for follow-up of a client post genetics/genomic referral.
  • Provision of education, care and support
    • PECS-1:   Provide clients with interpretation of genetic and genomic information
      • PECS1-K1:   Components of family history
        • PECS1-1:   Discuss factors in a family and health history that contribute to: disease susceptibility; disease characteristics, treatment, prognosis; or a genetic/genomic condition.
        • PECS1-2:   Use family history information to inform health education.
        • PECS1-3:   Discuss the role of genetic, genomic, environmental and psychosocial factors in the manifestation of disease.
        • PECS1-5:   Reinforce/clarify information provided by genetic professional to client (i.e., genetic test interpretation; informed consent).
      • PECS1-K2:   Inheritance Patterns
        • PECS1-1:   Discuss factors in a family and health history that contribute to: disease susceptibility; disease characteristics, treatment, prognosis; or a genetic/genomic condition.
        • PECS1-2:   Use family history information to inform health education.
        • PECS1-3:   Discuss the role of genetic, genomic, environmental and psychosocial factors in the manifestation of disease.
        • PECS1-5:   Reinforce/clarify information provided by genetic professional to client (i.e., genetic test interpretation; informed consent).
      • PECS1-K3:   Role of environmental and psychosocial factors
        • PECS1-1:   Discuss factors in a family and health history that contribute to: disease susceptibility; disease characteristics, treatment, prognosis; or a genetic/genomic condition.
        • PECS1-2:   Use family history information to inform health education.
        • PECS1-3:   Discuss the role of genetic, genomic, environmental and psychosocial factors in the manifestation of disease.
        • PECS1-5:   Reinforce/clarify information provided by genetic professional to client (i.e., genetic test interpretation; informed consent).
      • PECS1-K4:   Informed consent procedures and essential elements
        • PECS1-1:   Discuss factors in a family and health history that contribute to: disease susceptibility; disease characteristics, treatment, prognosis; or a genetic/genomic condition.
        • PECS1-2:   Use family history information to inform health education.
        • PECS1-3:   Discuss the role of genetic, genomic, environmental and psychosocial factors in the manifestation of disease.
        • PECS1-5:   Reinforce/clarify information provided by genetic professional to client (i.e., genetic test interpretation; informed consent).
    • PECS-2:   Provide clients with genetic and genomic information and resources for informed decision making
      • PECS2-K1:   Resources for healthcare professionals and lay public
        • PECS2-1:   Evaluate strengths, limitations, and best use of one genetic and/or genomic resource for a client or group of clients.
      • PECS2-K2:   Referral resources for genetic and genomic services within one's community
        • PECS2-1:   Evaluate strengths, limitations, and best use of one genetic and/or genomic resource for a client or group of clients.
      • PECS2-K3:   Roles of genetic/genomic health care professionals
        • PECS2-1:   Evaluate strengths, limitations, and best use of one genetic and/or genomic resource for a client or group of clients.
    • PECS-5:   Collaborate with health care providers to provide genetic and genomic health care in health promotion/disease prevention
      • PECS5-K1:   Roles of genetic/genomic health care professionals
        • PECS5-2:   Demonstrate team building and collaborative strategies when working with interprofessional teams.
      • PECS5-K2:   Roles of other genetic/genomic specialists
        • PECS5-2:   Demonstrate team building and collaborative strategies when working with interprofessional teams.
    • PECS-6:   Collaborate with insurance providers/payers to facilitate reimbursement for genetic and genomic health care
      • PECS6-K1:   Determinants of clinical utility of genetic/genomic tests
        • PECS6-1:   Identify strategies to facilitate reimbursement for genetic/genomic services and/or tests.
        • PECS6-2:   Describe other methods of payment for genetic/genomic health care services (i.e., laboratory indigent assistance programs).
      • PECS6-K2:   Economic impact of new genetic / genomic based therapies
        • PECS6-1:   Identify strategies to facilitate reimbursement for genetic/genomic services and/or tests.
        • PECS6-2:   Describe other methods of payment for genetic/genomic health care services (i.e., laboratory indigent assistance programs).
      • PECS6-K3:   Influence of predisposition gene variants, genetic disease/disorder on access to health
        • PECS6-1:   Identify strategies to facilitate reimbursement for genetic/genomic services and/or tests.
        • PECS6-2:   Describe other methods of payment for genetic/genomic health care services (i.e., laboratory indigent assistance programs).
    • PECS-7:   Performs interventions/treatments appropriate to clients' genetic and genomic healthcare needs.
      • PECS7-K1:   Pharmacogenetics, pharmacogenomics
        • PECS7-1:   Administer medications safely with consideration of pharmacogenetic test results if available.
        • PECS7-2:   Administer prescribed genetic / genomic based therapies safely as allowed per State Practice Act.
        • PECS7-3:   Teach client about purpose, expected benefits, limitations and potential risks of genetic/genomic based interventions.
      • PECS7-K2:   Gene or gene product targeted therapy
        • PECS7-1:   Administer medications safely with consideration of pharmacogenetic test results if available.
        • PECS7-2:   Administer prescribed genetic / genomic based therapies safely as allowed per State Practice Act.
        • PECS7-3:   Teach client about purpose, expected benefits, limitations and potential risks of genetic/genomic based interventions.
      • PECS7-K3:   Protein replacement therapy
        • PECS7-1:   Administer medications safely with consideration of pharmacogenetic test results if available.
        • PECS7-2:   Administer prescribed genetic / genomic based therapies safely as allowed per State Practice Act.
        • PECS7-3:   Teach client about purpose, expected benefits, limitations and potential risks of genetic/genomic based interventions.
      • PECS7-K4:   Chaperone therapy
        • PECS7-1:   Administer medications safely with consideration of pharmacogenetic test results if available.
        • PECS7-2:   Administer prescribed genetic / genomic based therapies safely as allowed per State Practice Act.
        • PECS7-3:   Teach client about purpose, expected benefits, limitations and potential risks of genetic/genomic based interventions.
    • PECS-8:   Evaluate impact and effectiveness of technology, information, interventions, and treatments
      • PECS8-K1:   Range of psychosocial responses
        • PECS8-1:   Assess client response to genetic/genomic information.
        • PECS8-2:   Assess client response to genetic/genomic based interventions.
        • PECS8-3:   Assess client response to genetic/genomic services.
        • PECS8-4:   Use evaluation of genetic/genomic technology, information and interventions to modify client's plan of care.
      • PECS8-K2:   Expected outcomes of various genetic/genomic based interventions
        • PECS8-1:   Assess client response to genetic/genomic information.
        • PECS8-2:   Assess client response to genetic/genomic based interventions.
        • PECS8-3:   Assess client response to genetic/genomic services.
        • PECS8-4:   Use evaluation of genetic/genomic technology, information and interventions to modify client's plan of care.

Physician

  • Family History
    • P-FH1A:   Patient Care
      • 1A1:   Conduct patient interview to assemble family history
      • 1A2:   Use standard pedigree symbols in assembling family history
      • 1A3:   Recognize patterns of Mendelian inheritance and calculate simple Mendelian risks; provide this information to patients and family members as appropriate
      • 1A4:   Use empirical risk figures to provide appropriate information for complex (multifactorial) medical conditions.
      • 1A5:   Recognize that traits may cluster in families due to multifactorial rather than Mendelian patterns of inheritance
      • 1A6:   Formulate an action plan to address relevant family history information
  • Patient Treatment Based on Genomic Results
    • P-PM3A:   Patient Care
      • 3A1:   Identify medical conditions and drug responses that have a strong genetic component
      • 3A2:   Recognize that variants affecting drug responses found in a patient may also have implications for other family members
      • 3A3:   Discern the potential clinical impact of genetic variation on risk stratification and individualized treatment
    • P-PM3B:   Knowledge for Practice
      • 3B1:   Appreciate the importance of genetic diversity of humans and the abundance of genetic variants in each individual genome
      • 3B2:   Identify single-gene disorders that may be amenable to targeted pharmacological therapy
      • 3B3:   Recognize that genomic test results may guide choice of therapy for multifactorial disorders
      • 3B4:   Recognize that there is variability in the phenotypic expression of genetic variants and in response to therapy
      • 3B5:   Recognize that the effects of some medications are strongly influenced by inherited or somatically acquired genetic variation

Genetic Counselor

  • Genetics Expertise and Analysis
    • 4:   Identify, assess, facilitate, and integrate genetic testing options in genetic counseling practice.
      • 4a:   Investigate the availability, analytic validity, clinical validity, and clinical utility of screening, diagnostic and predictive genetic/genomic tests.
      • 4b:   Evaluate and assess laboratories and select the most appropriate laboratory and test based on the clinical situation.
      • 4c:   Identify and discuss the potential benefits, risks, limitations and costs of genetic testing.
      • 4d:   Coordinate and facilitate the ordering of appropriate genetic testing for the client.
      • 4e:   Interpret the clinical implications of genetic test reports.
      • 4f:   Recognize and differentiate specific considerations relevant to genetic versus genomic and clinical versus research testing in terms of the informed consent process, results disclosure, institutional review board (IRB) guidelines, and clinical decision-making.