Bayesian Risk Assessment in Genetic Testing for Autosomal Dominant Disorders with Age-Dependent Penetrance.

This peer-reviewed article describes how to use Bayesian analysis in risk assessment for autosomal dominant conditions with age-related penetrance using a number of illustrative examples.

Some examples include incorporating the results of genetic testing in addition to penetrance information.

This article could be used to develop a lecture for classroom presentation or as a reading/self-study.

Type Article
CME Available No
Cost Free to NSGC Members


Genomic Competencies

Experts from the disciplines listed below have tagged this resource as fulfulling genomic competencies.

Genetic Counselor

  • Genetics Expertise and Analysis
    • 5:   Assess individuals' and their relatives' probability of conditions with a genetic component or carrier status based on their pedigree, test result(s), and other pertinent information.
      • 5a:   Assess probability of conditions with a genetic component or carrier status using relevant knowledge and data based on pedigree analysis, inheritance patterns, genetic epidemiology, quantitative genetics principles, and mathematical calculations.
      • 5b:   Incorporate the results of screening, diagnostic and predictive genetic/genomic tests to provide accurate risk assessment for clients.
      • 5c:   Evaluate familial implications of genetic/genomic test results.
      • 5d:   Identify and integrate relevant information about environmental and lifestyle factors into the risk assessment.