Bayesian Risk Assessment in Genetic Testing for Autosomal Dominant Disorders with Age-Dependent Penetrance.

This peer-reviewed article describes how to use Bayesian analysis in risk assessment for autosomal dominant conditions with age-related penetrance using a number of illustrative examples.

Some examples include incorporating the results of genetic testing in addition to penetrance information.

This article could be used to develop a lecture for classroom presentation or as a reading/self-study.

Type Article
CME Available No
Cost Free to NSGC Members


Date of Resource 2007

Genomic Competencies

Experts from the disciplines listed below have tagged this resource as fulfulling genomic competencies.

Genetic Counselor

  • Genetics Expertise and Analysis
    • 5:   Assess individuals' and their relatives' probability of conditions with a genetic component or carrier status based on their pedigree, test result(s), and other pertinent information.
      • 5a:   Assess probability of conditions with a genetic component or carrier status using relevant knowledge and data based on pedigree analysis, inheritance patterns, genetic epidemiology, quantitative genetics principles, and mathematical calculations.
      • 5b:   Incorporate the results of screening, diagnostic and predictive genetic/genomic tests to provide accurate risk assessment for clients.
      • 5c:   Evaluate familial implications of genetic/genomic test results.
      • 5d:   Identify and integrate relevant information about environmental and lifestyle factors into the risk assessment.