Clinical Pharmacogenetics Implementation Consortium (CPIC)

The Clinical Pharmacogenetics Implementation Consortium (CPIC) was formed as a shared project between PharmGKB and the Pharmacogenomics Research Network (PGRN). CPIC guidelines are peer-reviewed and published in a leading journal (in partnership with Clinical Pharmacology and Therapeutics) with simultaneous posting to PharmGKB with supplemental information/data and updates. Anyone with clinical interests in pharmacogenetics is eligible for membership. CPIC’s goal is to address some of the barriers to implementation of pharmacogenetic tests into clinical practice. One barrier to clinical implementation of pharmacogenetics is the lack of freely available, peer-reviewed, updatable, and detailed gene/drug clinical practice guidelines. CPIC provides guidelines that enable the translation of genetic laboratory test results into actionable prescribing decisions for specific drugs. The guidelines can center on genes (e.g. thiopurine methyltransferase and its implications for thiopurines) or around drugs (e.g. warfarin and CYP2C9 and VKORC1). Priority is given to genotyping tests that are already offered in CLIA-approved clinical settings.


Type Website
CME Available No
Topic
Cost Free
Note



Genomic Competencies

Experts from the disciplines listed below have tagged this resource as fulfulling genomic competencies.

Pharmacist

  • Genetics and Disease
    • G3:   To appreciate that pharmacogenomic testing may also reveal certain genetic disease predispositions (e.g. the Apo E4 polymorphism)
  • Pharmacogenetics/Pharmacogenomics
    • P1:   To demonstrate an understanding of how genetic variation in a large number of proteins, including drug transporters, drug metabolizing enzymes, direct protein targets of drugs, and other proteins (e.g. signal transduction proteins) influence pharmacokinetics and pharmacodynamics related to pharmacologic effect and drug response
    • P2:   To understand the influence (or lack thereof) of ethnicity in genetic polymorphisms and associations of polymorphisms with drug response
    • P3:   Recognize the availability of evidence based guidelines that synthesize information relevant to genomic/pharmacogenomic tests and selection of drug therapy (e.g. Clinical Pharmacogenomics Implementation Consortium)

Physician Assistant

  • Patient Care
    • 3:   Distinguish between genetic screening and genetic testing
    • 4:   Incorporate genetic tests into patient management

Nurse

  • Professional Responsibilities
    • PR-4:   Incorporate genetic and genomic technologies and information into practice.
      • PR4-K1:   Technology and information systems
        • PR4-1:   Evaluate genetic and genomic technologies used in client care.
        • PR4-2:   Demonstrate use of genetic and genomic technology and client data for clinical decision-making in providing safe client care.
        • PR4-3:   Identify the credibility, reliability and limitations of genetic and genomic information.
        • PR4-4:   Identify ethical, legal, and social issues associated with genetic/genomic information.
    • PR-5:   Demonstrate the importance of tailoring genetic and genomic information and services
      • PR5-K1:   Cultural, social, ethnic and religious perspectives
        • PR5-1:   Incorporate client's cultural, social, ethnic and religious perspective and literacy level when delivering genetic and genomic care.
        • PR5-2:   Integrate knowledge from psychology, history, politics, sociology and culture when delivering genetic and genomic care.
      • PR5-K2:   Economic and health disparities
        • PR5-1:   Incorporate client's cultural, social, ethnic and religious perspective and literacy level when delivering genetic and genomic care.
        • PR5-2:   Integrate knowledge from psychology, history, politics, sociology and culture when delivering genetic and genomic care.
  • Nursing Assessment
    • NA-1:   Demonstrate understanding of relationship of genetics and genomics to health
      • NA1-K1:   Relationship of genetics and genomics to health
        • NA1-1:   Collect a client's personal and three generation family health history to assess for genomic factors that impact the client's health.
        • NA1-2:   Identify potentially significant information from a family history.
        • NA1-3:   Identify clients who might benefit from referral to genetic specialists and/or information resources.
        • NA1-4:   Facilitate appropriate referral to genetic specialists, accurately documenting and communicating relevant history and clinical data.
        • NA1-5:   Describe a typical client journey that might be experienced in the process of genetic counseling.
        • NA1-6:   Describe genetic/genomic factors that contribute to variability of response to pharmacologic agents.
        • NA1-7:   Incorporate genetic and genomic health assessment data into routinely collected biopsychosocial and environmental assessments of health and illness parameters in client, using culturally sensitive approaches.
        • NA1-8:   Identify resources available to assist clients seeking genetic and genomic information or services including the types of services available.
      • NA1-K2:   Relationship of genetics and genomics to normal physiology and pathophysiology
        • NA1-1:   Collect a client's personal and three generation family health history to assess for genomic factors that impact the client's health.
        • NA1-2:   Identify potentially significant information from a family history.
        • NA1-3:   Identify clients who might benefit from referral to genetic specialists and/or information resources.
        • NA1-4:   Facilitate appropriate referral to genetic specialists, accurately documenting and communicating relevant history and clinical data.
        • NA1-5:   Describe a typical client journey that might be experienced in the process of genetic counseling.
        • NA1-6:   Describe genetic/genomic factors that contribute to variability of response to pharmacologic agents.
        • NA1-7:   Incorporate genetic and genomic health assessment data into routinely collected biopsychosocial and environmental assessments of health and illness parameters in client, using culturally sensitive approaches.
        • NA1-8:   Identify resources available to assist clients seeking genetic and genomic information or services including the types of services available.
      • NA1-K3:   Basic principles of pharmacogenetics and pharmacogenomics
        • NA1-1:   Collect a client's personal and three generation family health history to assess for genomic factors that impact the client's health.
        • NA1-2:   Identify potentially significant information from a family history.
        • NA1-3:   Identify clients who might benefit from referral to genetic specialists and/or information resources.
        • NA1-5:   Describe a typical client journey that might be experienced in the process of genetic counseling.
        • NA1-6:   Describe genetic/genomic factors that contribute to variability of response to pharmacologic agents.
        • NA1-7:   Incorporate genetic and genomic health assessment data into routinely collected biopsychosocial and environmental assessments of health and illness parameters in client, using culturally sensitive approaches.
        • NA1-8:   Identify resources available to assist clients seeking genetic and genomic information or services including the types of services available.
      • NA1-K4:   Patterns of disease associated with single gene and multifactorial inheritance
        • NA1-1:   Collect a client's personal and three generation family health history to assess for genomic factors that impact the client's health.
        • NA1-2:   Identify potentially significant information from a family history.
        • NA1-3:   Identify clients who might benefit from referral to genetic specialists and/or information resources.
        • NA1-4:   Facilitate appropriate referral to genetic specialists, accurately documenting and communicating relevant history and clinical data.
        • NA1-5:   Describe a typical client journey that might be experienced in the process of genetic counseling.
        • NA1-6:   Describe genetic/genomic factors that contribute to variability of response to pharmacologic agents.
        • NA1-8:   Identify resources available to assist clients seeking genetic and genomic information or services including the types of services available.
    • NA-5:   Conducts assessments incorporating genetic, environmental, and genomic influences and risk factors
      • NA5-K1:   Fundamentals of genetic and genomic focused health and physical assessment
        • NA1-7:   Incorporate genetic and genomic health assessment data into routinely collected biopsychosocial and environmental assessments of health and illness parameters in client, using culturally sensitive approaches.
      • NA5-K2:   Basics of risk factors
        • NA1-7:   Incorporate genetic and genomic health assessment data into routinely collected biopsychosocial and environmental assessments of health and illness parameters in client, using culturally sensitive approaches.
    • NA-8:   Develop a plan of care that incorporates genetic and genomic assessment information.
      • NA8-K1:   Interprofessional plan of care
        • NA8-1:   Develop, in partnership with the client, a health care plan that takes into account genetic and genomic determinants of health, available resources, and range of activities that contribute to health and prevention of illness, injury, disability and premat
        • NA8-2:   Integrate best evidence, clinical judgment, client preferences, and family implications in planning genetic and genomic focused individualized care.
  • Identification
    • ID-2:   Identify credible, accurate, appropriate, and current genetic and genomic information
      • ID2-K1:   Resources for health care professionals and lay public
        • ID2-1:   Evaluate strengths, limitations, and best use of genetic and/or genomic resource for a client or group of clients.
        • ID2-2:   Discuss the ways in which nurses can meet the educational, psychosocial and resource needs of clients and families affected by a genetic or genomic condition.
        • ID2-3:   Discuss the ways in which nurses can meet the knowledge, psychosocial and resource needs of clients and families affected by genetic/genomic technology.
        • ID2-4:   Identify resources available to assist clients seeking genetic and genomic information or services including the types of services available.
        • ID2-5:   Develop a list of contacts and resources for genetic/genomic referrals.
        • ID2-6:   Evaluate sources of evidence and clinical practice guidelines for a client whose care involves genetic and/or genomic health care. Use continuous quality improvement initiatives to update practice guidelines as necessary.
      • ID2-K2:   Resources for referral within one's community
        • ID2-1:   Evaluate strengths, limitations, and best use of genetic and/or genomic resource for a client or group of clients.
        • ID2-2:   Discuss the ways in which nurses can meet the educational, psychosocial and resource needs of clients and families affected by a genetic or genomic condition.
        • ID2-3:   Discuss the ways in which nurses can meet the knowledge, psychosocial and resource needs of clients and families affected by genetic/genomic technology.
        • ID2-4:   Identify resources available to assist clients seeking genetic and genomic information or services including the types of services available.
        • ID2-5:   Develop a list of contacts and resources for genetic/genomic referrals.
        • ID2-6:   Evaluate sources of evidence and clinical practice guidelines for a client whose care involves genetic and/or genomic health care. Use continuous quality improvement initiatives to update practice guidelines as necessary.
      • ID2-K3:   Roles of genetic/genomic health care professionals
        • ID2-1:   Evaluate strengths, limitations, and best use of genetic and/or genomic resource for a client or group of clients.
        • ID2-2:   Discuss the ways in which nurses can meet the educational, psychosocial and resource needs of clients and families affected by a genetic or genomic condition.
        • ID2-3:   Discuss the ways in which nurses can meet the knowledge, psychosocial and resource needs of clients and families affected by genetic/genomic technology.
        • ID2-4:   Identify resources available to assist clients seeking genetic and genomic information or services including the types of services available.
        • ID2-5:   Develop a list of contacts and resources for genetic/genomic referrals.
        • ID2-6:   Evaluate sources of evidence and clinical practice guidelines for a client whose care involves genetic and/or genomic health care. Use continuous quality improvement initiatives to update practice guidelines as necessary.
      • ID2-K4:   Interprofessional resources
        • ID2-1:   Evaluate strengths, limitations, and best use of genetic and/or genomic resource for a client or group of clients.
        • ID2-2:   Discuss the ways in which nurses can meet the educational, psychosocial and resource needs of clients and families affected by a genetic or genomic condition.
        • ID2-3:   Discuss the ways in which nurses can meet the knowledge, psychosocial and resource needs of clients and families affected by genetic/genomic technology.
        • ID2-4:   Identify resources available to assist clients seeking genetic and genomic information or services including the types of services available.
        • ID2-5:   Develop a list of contacts and resources for genetic/genomic referrals.
        • ID2-6:   Evaluate sources of evidence and clinical practice guidelines for a client whose care involves genetic and/or genomic health care. Use continuous quality improvement initiatives to update practice guidelines as necessary.
  • Referral activities
    • RA-1:   Facilitate referrals for specialized genetic and genomic services
      • RA1-K1:   Professional roles of providers delivering genetic and genomic services
        • ID2-5:   Develop a list of contacts and resources for genetic/genomic referrals.
      • RA1-K2:   Resources for health care professionals and lay public
        • ID2-5:   Develop a list of contacts and resources for genetic/genomic referrals.
      • RA1-K3:   Resources for genetic and genomic referrals within the community
        • ID2-5:   Develop a list of contacts and resources for genetic/genomic referrals.
  • Provision of education, care and support
    • PECS-1:   Provide clients with interpretation of genetic and genomic information
      • PECS1-K1:   Components of family history
        • PECS1-1:   Discuss factors in a family and health history that contribute to: disease susceptibility; disease characteristics, treatment, prognosis; or a genetic/genomic condition.
        • PECS1-2:   Use family history information to inform health education.
        • PECS1-3:   Discuss the role of genetic, genomic, environmental and psychosocial factors in the manifestation of disease.
        • PECS1-5:   Reinforce/clarify information provided by genetic professional to client (i.e., genetic test interpretation; informed consent).
      • PECS1-K2:   Inheritance Patterns
        • PECS1-1:   Discuss factors in a family and health history that contribute to: disease susceptibility; disease characteristics, treatment, prognosis; or a genetic/genomic condition.
        • PECS1-2:   Use family history information to inform health education.
        • PECS1-3:   Discuss the role of genetic, genomic, environmental and psychosocial factors in the manifestation of disease.
        • PECS1-5:   Reinforce/clarify information provided by genetic professional to client (i.e., genetic test interpretation; informed consent).
      • PECS1-K3:   Role of environmental and psychosocial factors
        • PECS1-1:   Discuss factors in a family and health history that contribute to: disease susceptibility; disease characteristics, treatment, prognosis; or a genetic/genomic condition.
        • PECS1-2:   Use family history information to inform health education.
        • PECS1-3:   Discuss the role of genetic, genomic, environmental and psychosocial factors in the manifestation of disease.
        • PECS1-5:   Reinforce/clarify information provided by genetic professional to client (i.e., genetic test interpretation; informed consent).
      • PECS1-K4:   Informed consent procedures and essential elements
        • PECS1-1:   Discuss factors in a family and health history that contribute to: disease susceptibility; disease characteristics, treatment, prognosis; or a genetic/genomic condition.
        • PECS1-2:   Use family history information to inform health education.
        • PECS1-3:   Discuss the role of genetic, genomic, environmental and psychosocial factors in the manifestation of disease.
        • PECS1-5:   Reinforce/clarify information provided by genetic professional to client (i.e., genetic test interpretation; informed consent).
    • PECS-2:   Provide clients with genetic and genomic information and resources for informed decision making
      • PECS2-K1:   Resources for healthcare professionals and lay public
        • ID2-5:   Develop a list of contacts and resources for genetic/genomic referrals.
        • PECS2-1:   Evaluate strengths, limitations, and best use of one genetic and/or genomic resource for a client or group of clients.
        • PECS2-2:   Help clients interpret and understand genetic and genomic information.
      • PECS2-K2:   Referral resources for genetic and genomic services within one's community
        • ID2-5:   Develop a list of contacts and resources for genetic/genomic referrals.
        • PECS2-1:   Evaluate strengths, limitations, and best use of one genetic and/or genomic resource for a client or group of clients.
        • PECS2-2:   Help clients interpret and understand genetic and genomic information.
      • PECS2-K3:   Roles of genetic/genomic health care professionals
        • ID2-5:   Develop a list of contacts and resources for genetic/genomic referrals.
        • PECS2-1:   Evaluate strengths, limitations, and best use of one genetic and/or genomic resource for a client or group of clients.
        • PECS2-2:   Help clients interpret and understand genetic and genomic information.
    • PECS-3a:   Use health promotion/disease prevention practices that consider genetic and genomic influences
      • PECS3-K1:   Role of environmental and psychosocial factors
        • NA1-7:   Incorporate genetic and genomic health assessment data into routinely collected biopsychosocial and environmental assessments of health and illness parameters in client, using culturally sensitive approaches.
      • PECS3-K2:   Fundamentals of epidemiology and biostatistics
        • NA1-7:   Incorporate genetic and genomic health assessment data into routinely collected biopsychosocial and environmental assessments of health and illness parameters in client, using culturally sensitive approaches.
      • PECS3-K3:   Ongoing research contributing to improved understanding of the genetic/genomic influences on health
        • NA1-7:   Incorporate genetic and genomic health assessment data into routinely collected biopsychosocial and environmental assessments of health and illness parameters in client, using culturally sensitive approaches.
    • PECS-3b:   Use health promotion/disease prevention practices incorporating knowledge of genetic and/or genomic risk factors
      • NA1-7:   Incorporate genetic and genomic health assessment data into routinely collected biopsychosocial and environmental assessments of health and illness parameters in client, using culturally sensitive approaches.

Genetic Counselor

  • Genetics Expertise and Analysis
    • 1:   Demonstrate and utilize a depth and breadth of understanding and knowledge of genetics and genomics core concepts and principles.
      • 1a:   Demonstrate knowledge of principles of human, medical, and public health genetics and genomics and their related sciences.
      • 1b:   Apply knowledge of genetic principles and understand how they contribute to etiology, clinical features and disease expression, natural history, differential diagnoses, genetic testing and test report interpretation, pathophysiology, recurrence risk, management and prevention, and population screening.
    • 3:   Construct relevant, targeted and comprehensive personal and family histories and pedigrees.
      • 3a:   Demonstrate proficiency in the use of pedigree symbols, standard notation, and nomenclature.
      • 3b:   Utilize interviewing skills to elicit a family history and pursue a relevant path of inquiry.
    • 4:   Identify, assess, facilitate, and integrate genetic testing options in genetic counseling practice.
      • 4a:   Investigate the availability, analytic validity, clinical validity, and clinical utility of screening, diagnostic and predictive genetic/genomic tests.
      • 4b:   Evaluate and assess laboratories and select the most appropriate laboratory and test based on the clinical situation.
      • 4c:   Identify and discuss the potential benefits, risks, limitations and costs of genetic testing.
      • 4d:   Coordinate and facilitate the ordering of appropriate genetic testing for the client.
      • 4e:   Interpret the clinical implications of genetic test reports.
      • 4f:   Recognize and differentiate specific considerations relevant to genetic versus genomic and clinical versus research testing in terms of the informed consent process, results disclosure, institutional review board (IRB) guidelines, and clinical decision-making.
    • 7:   Critically assess genetic/genomic, medical and social science literature and information.
      • 7a:   Plan and execute a thorough search and review of the literature.
      • 7b:   Evaluate and critique scientific papers and identify appropriate conclusions by applying knowledge of relevant research methodologies and statistical analyses.
      • 7c:   Synthesize information obtained from a literature review to utilize in genetic counseling encounters.
      • 7d:   Incorporate medical and scientific literature into evidenced-based practice recognizing that there are limitations and gaps in knowledge and data.
  • Professional Development & Practice
    • 20:   Support client and community interests in accessing, or declining, social and health services and clinical research.
      • 20a:   Display initiative for lifelong learning.
      • 20b:   Recognize one's limitations and capabilities in the context of genetic counseling practice.
      • 20c:   Seek feedback and respond appropriately to performance critique.
      • 20d:   Demonstrate a scholarly approach to genetic counseling, including using available evidence-based principles in the preparation and execution of a genetic counseling encounter.
      • 20e:   Identify appropriate individual and/or group opportunities for ongoing personal supervision and mentorship.
      • 20f:   Accept responsible for one's physical and emo- tional health as it impacts on professional performance.
      • 20g:   Recognize and respect professional boundaries between clients, colleagues, and supervisors.