CDC Public Health Genomics Knowledge Base

The CDC Public Health Genomics Knowledge Base is an online, searchable database of published scientific literature, CDC resources, and other material that addresses the translation of genomic discoveries into improved health care and disease prevention. The Knowledge Base is curated by CDC staff and is regularly updated to reflect ongoing developments in the field. This compendium of databases can be searched for genomics-related information on any specific topic.



Type Website
CME Available No
Topic
Cost Free
Note



Genomic Competencies

Experts from the disciplines listed below have tagged this resource as fulfulling genomic competencies.

Pharmacist

  • Basic Genetic Concepts
    • B3:   To identify drug and disease associated genetic variations that facilitate development of prevention, diagnostic and treatment strategies and appreciate there are differences in testing methodologies and are aware of the need to explore these differences these differences in drug literature evaluation
    • B4:   To use family history (minimum of three generations) in assessing predisposition to disease and selection of drug treatment
  • Ethical, Legal and Social Implications (ELSI)
    • E1:   To understand the potential physical and/or psychosocial benefits, limitations and risk of genomic/pharmacogenomic information for individuals, family members and communities, especially with genomic/pharmacogenomic tests that may relate to predisposition to disease
    • E2:   To understand the increased liability that accompanies access to detailed genomic patient information and maintain confidentiality and security
    • E3:   To adopt a culturally sensitive and ethical approach to patient counseling regarding genomic/pharmacogenomic test results
    • E4:   To appreciate the cost, cost-effectiveness, and reimbursement by insurers relevant to genomic or pharmacogenomic tests and test interpretation, for patients and populations
  • Genetics and Disease
    • G1:   To understand the role of genetic factors in maintaining health and preventing disease
    • G2:   To assess the difference between clinical diagnosis of disease and identification of genetic predisposition to disease (genetic variation is not strictly correlated with disease manifestation)
    • G3:   To appreciate that pharmacogenomic testing may also reveal certain genetic disease predispositions (e.g. the Apo E4 polymorphism)
  • Pharmacogenetics/Pharmacogenomics
    • P1:   To demonstrate an understanding of how genetic variation in a large number of proteins, including drug transporters, drug metabolizing enzymes, direct protein targets of drugs, and other proteins (e.g. signal transduction proteins) influence pharmacokinetics and pharmacodynamics related to pharmacologic effect and drug response
    • P2:   To understand the influence (or lack thereof) of ethnicity in genetic polymorphisms and associations of polymorphisms with drug response
    • P3:   Recognize the availability of evidence based guidelines that synthesize information relevant to genomic/pharmacogenomic tests and selection of drug therapy (e.g. Clinical Pharmacogenomics Implementation Consortium)

Nurse

  • Professional Responsibilities
    • PR-3:   Examine competency of practice
      • PR3-K1:   Scope of nursing practice in relation to genetics/genomics
        • PR3-1:   Identify relevance of genetics/genomics to practice of your discipline.
        • PR3-2:   Demonstrate awareness of the boundaries of one's own professional practice in relation to genetics/genomics.
        • PR3-3:   Perform regular self assessments to identify knowledge and skills deficits that could impact the quality of nursing care one provides to clients in need of genetic/genomic guidance, referral and resources.
        • PR3-4:   Take action to meet identified knowledge and skills deficits related to genetics and genomics.
      • PR3-K2:   Role of specialist genetic/genomic services
        • PR3-1:   Identify relevance of genetics/genomics to practice of your discipline.
        • PR3-2:   Demonstrate awareness of the boundaries of one's own professional practice in relation to genetics/genomics.
        • PR3-3:   Perform regular self assessments to identify knowledge and skills deficits that could impact the quality of nursing care one provides to clients in need of genetic/genomic guidance, referral and resources.
        • PR3-4:   Take action to meet identified knowledge and skills deficits related to genetics and genomics.
      • PR3-K3:   Interprofessional resources
        • PR3-1:   Identify relevance of genetics/genomics to practice of your discipline.
        • PR3-2:   Demonstrate awareness of the boundaries of one's own professional practice in relation to genetics/genomics.
        • PR3-3:   Perform regular self assessments to identify knowledge and skills deficits that could impact the quality of nursing care one provides to clients in need of genetic/genomic guidance, referral and resources.
        • PR3-4:   Take action to meet identified knowledge and skills deficits related to genetics and genomics.

Physician

  • Genomic Testing
    • P-GT2A:   Patient Care
      • 2A1:   Discuss the indications for genomic testing - specifically the benefits, risks, and alternatives
      • 2A2:   Explain the implications of placing genomic test results in the patient’s medical record
      • 2A3:   Discuss the possibility of incidental findings and how they will be handled
      • 2A4:   Discuss risks of having genomic testing done: e.g., psychological implications for the individual as well as the family; the potential for discrimination; and the potential effect on insurance coverage.
      • 2A5:   Explain to the patient issues of costs and financial coverage of genomic testing
      • 2A6:   Order, interpret, and communicate the results of appropriate genomic tests, within the physician’s scope of practice
      • 2A7:   Provide referral to an appropriate specialist for genomic testing of a condition outside the physician’s scope of practice
      • 2A8:   Respond to the results of an abnormal genetic screening test, such as newborn screening, including immediate management and appropriate referral
    • P-GT2B:   Knowledge for Practice
      • 2B1:   Describe the major forms of genomic variability
      • 2B2:   Explain how different genomic changes may result in different phenotypes
      • 2B3:   Recognize that genomic tests require interpretation with respect to the patient’s clinical status (e.g., pathogenic, likely pathogenic, benign)
      • 2B4:   Explain the concepts of analytic validity, clinical validity, clinical utility as they relate to genomic testing
      • 2B5:   Recognize that medically ’non-actionable’ genomic results can be useful to the patient and family (i.e., personal utility)
    • P-GT2H:   Personal and Professional Development
      • 2H1:   Engage in continuing education regarding advances in genomic medicine and changing indications for and interpretation of genomic testing
  • Patient Treatment Based on Genomic Results
    • P-PM3A:   Patient Care
      • 3A1:   Identify medical conditions and drug responses that have a strong genetic component
      • 3A2:   Recognize that variants affecting drug responses found in a patient may also have implications for other family members
      • 3A3:   Discern the potential clinical impact of genetic variation on risk stratification and individualized treatment
    • P-PM3B:   Knowledge for Practice
      • 3B1:   Appreciate the importance of genetic diversity of humans and the abundance of genetic variants in each individual genome
      • 3B2:   Identify single-gene disorders that may be amenable to targeted pharmacological therapy
      • 3B3:   Recognize that genomic test results may guide choice of therapy for multifactorial disorders
      • 3B4:   Recognize that there is variability in the phenotypic expression of genetic variants and in response to therapy
      • 3B5:   Recognize that the effects of some medications are strongly influenced by inherited or somatically acquired genetic variation
    • P-PM3C:   Practice-Based Learning and Improvement
      • 3C1:   Use evidence-based recommendations of professional organizations and others in implementing knowledge gained from genetic discoveries to improve therapeutics
      • 3C2:   Document and periodically reassess therapeutic decision-making into the medical record of patients
      • 3C3:   Incorporate a realistic assessment of personal genomic knowledge and skill in the selection and use of consultants and improve competencies in the wake of these interactions
    • P-PM3H:   Personal and Professional Development
      • 3H1:   Maintain the medical knowledge and clinical competence in genomics required for the provision of therapy
      • 3H2:   Be familiar with the available databases and resources relevant to genetic variation, including ongoing clinical trials involving patients with genetic disorders, pharmacogenomics, and patient-oriented Internet resources from reliable organizations
  • Somatic Genomics
    • P-SG4A:   Patient Care
      • 4A1:   Identify or facilitate identification of patients who may benefit from genomic testing of tissue
      • 4A2:   Explain the benefits and limitations of somatic genomic testing to the patient, including implications regarding treatment of their condition and clarification of his/her prognosis
      • 4A3:   Ensure that tissue biopsy procedures are coordinated to make certain that appropriate and sufficient material is obtained for testing
      • 4A4:   Integrate genomic testing results into the patient-care plan
    • P-SG4B:   Knowledge for Practice
      • 4B1:   Explain the concept of somatic genetic change
      • 4B2:   Describe the role of genomic changes in the pathophysiology and treatment of cancer
      • 4B3:   Explain how genomic testing can be used to guide choice of therapy and adjust drug dosage in patients with cancer
    • P-SG4C:   Practice-Based Learning and Improvement
      • 4C1:   Maintain an awareness of and follow evidence-based guidelines and other professional resources regarding somatic genetic disorders appropriate to the physician’s scope of practice
    • P-SG4H:   Personal and Professional Development
      • 4H1:   Keep up-to-date with progress in the diagnosis and treatment of cancer and other tissue-based disorders
  • Microbial Genomic Information
    • P-MG5A:   Patient Care
      • 5A1:   Use genomic-based tests for infectious disease instead of classical strategies where appropriate (e.g., based on clinical validity and turn-around time)
      • 5A2:   Appreciate the sensitivity and specificity of genomics-based tests for diagnosis of infectious disease based on the clinical presentation, suspected pathogen type and testing method
      • 5A3:   Interpret genomics-based tests for diagnosis, monitoring, and treatment of infectious disease
    • P-MG5B:   Knowledge for Practice
      • 5B1:   Explain the core strategies for genomic testing for microbial disease
      • 5B2:   Describe how DNA or RNA sequence variations in the microbiome may predict response to therapy and clinical outcomes
      • 5B3:   Explain the potential reasons for false-positive and false-negative microbial genomic-based tests
      • 5B4:   Explain the importance of ’normal’ microbiome to health and disease
    • P-MG5C:   Practice-Based Learning and Improvement
      • 5C1:   Monitor ongoing testing results and their implications for treatment and prognosis in chronic infection
      • 5C2:   Be aware of new genomic testing methods and their clinical applications and apply when appropriate
      • 5C3:   Maintain awareness of patterns of infection in your patient population and use genomic tests appropriate to these patterns
    • P-MG5H:   Personal and Professional Development
      • 5H1:   Maintain up-to-date knowledge on genomic approaches to care for patients with microbial infection

Genetic Counselor

  • Genetics Expertise and Analysis
    • 7:   Critically assess genetic/genomic, medical and social science literature and information.
      • 7a:   Plan and execute a thorough search and review of the literature.
      • 7b:   Evaluate and critique scientific papers and identify appropriate conclusions by applying knowledge of relevant research methodologies and statistical analyses.
      • 7c:   Synthesize information obtained from a literature review to utilize in genetic counseling encounters.
      • 7d:   Incorporate medical and scientific literature into evidenced-based practice recognizing that there are limitations and gaps in knowledge and data.